OPUS 12 Scientist, Volume 4, Number 1 (Jan-Jun 2010)

Correlation between CCL20 and serum glucose in postoperative coronary bypass patient: A call for further investigation

Thomas J. Papadimos, Scott M. Pappada, Jason D. Lather, Vassili Bazalitski, S. Peter Stawicki, Brent D. Cameron, Z. Kevin Pan

Abstract


Insulin administration during cardiopulmonary bypass grafting (CABG) and in the perioperative period has been shown to lower TNF-alpha, IL-6, and IL-8 levels, which are considered to be mediators of immunity and inflammation. It is not known whether perioperative hyperglycemia attenuates the action of lymphocyte attracting chemokines such as CCL20 [(CC-motif) ligand 20], also known as macrophage inflammatory protein 3, MIP-3a; or liver activation regulated chemokine, LARC. CCL20 is a selective chemoattractant for immature dendritic cells, effector/memory T lymphocytes and naïve B cells, and is recognized as a critical regulator of both innate and acquired immunity. In this report, we describe our preliminary findings of the interaction between serum blood glucose and CCL20. Specifically, we report an increase in CCL20 temporally associated with improving glycemic control in a diabetic patient undergoing intensive insulin therapy after open heart surgery.

Citation: Papadimos TJ, Pappada SM, Lather JD, Bazalitski V, Stawicki SP, Cameron BD, Pan ZK. Correlation between CCL20 and serum glucose in postoperative coronary bypass patient: A call for further investigation. OPUS 12 Scientist 2010; 4(1):1-2.

Keywords: Cytokines, Chemokines, Cardiac surgery, Wound healing, Critical care, Diabetes, Glucose.

Copyright 2007-2010 OPUS 12 Foundation, Inc.

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